Mitochondrial Translation
Gene co-expression module in Innate lymphoid cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 46 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 46 genes have a known function matching the annotation |
Why this annotation
Hub genes include CHCHD1 (mitochondrial coiled-coil domain protein), MRPL57, MRPS33, MRPL20, MRPS12 (mitochondrial ribosomal proteins, large and small subunit), EIF5B and EIF3A (translation initiation factors), MCTS1 (translation re-initiation factor), SNRNP40 (spliceosome U5 snRNP), PSMC6 (proteasome 26S ATPase). The dominant theme is mitochondrial ribosome subunits (4 MRPL/MRPS genes with strong/core membership) combined with cytoplasmic translation factors. This reflects active mitochondrial translation and protein synthesis, consistent with ILC1 enrichment. Neighbors M74 and M62 share OxPhos/proteasome themes supporting a metabolically active ILC1 state.
Genes
ABCF1, ARGLU1, ATG12, BAG1, C1orf35, CHCHD1, CHMP5, DNAJC7, EIF2S2, EIF3A, EIF5B, EIF6, FAM32A, LLPH, MCTS1, MESD, MPLKIP, MRPL20, MRPL57, MRPS12, MRPS33, NAA20, NEMF, NUCKS1, PDAP1, PDCD5, PDCD6, PFDN2, PSMC6, PSMD1, PSMG2, RAB18, SCCPDH, SH3GLB1, SNRNP40, SNX6, SRP19, SSBP1, SSU72, TBCA, TM2D1, TMEM208, TTC1, TUSC2, TXNL1, UBE2I
Most correlated modules
- Proteasome ER Proteostasis · correlation 0.97
- RNA Splicing Processing · correlation 0.95
- Mitochondrial OxPhos · correlation 0.94
- RNA Chromatin Regulation · correlation 0.94
- DNA Damage Response · correlation 0.94
- Actin Cytoskeleton Remodeling · correlation 0.93
- Endosomal Trafficking Signaling · correlation 0.93
- ER-Golgi Trafficking · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.