Lysosomal Autophagy Trafficking
Gene co-expression module in Colonocytes
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 21 genes have a known function matching the annotation |
Why this annotation
Key hub genes SCARB2 (lysosomal integral membrane protein LIMP-2), SLC17A5 (sialin, lysosomal sialic acid transporter), LITAF (lysosome-associated and NF-κB-linked trafficking regulator), RETREG1 (FAM134B, ER-phagy/reticulophagy receptor), STX12 (syntaxin-12, endosomal/recycling vesicle fusion), CHMP2A (ESCRT-III, shared with neighbor M75), and NDFIP2 (Nedd4-family adaptor for ubiquitin-mediated lysosomal targeting) collectively define a lysosomal and autophagic trafficking program. WASL (N-WASP) and PDLIM1 contribute actin remodeling for autophagosome/lysosome dynamics. HIGD1A suggests a mild hypoxic/metabolic stress context activating this pathway. INAVA and CXADR link to epithelial barrier maintenance. The module is a lysosomal/autophagy trafficking program, distinguished from neighbor M75's endosomal sorting by its lysosomal membrane proteins and reticulophagy receptor.
Genes
Most correlated modules
- Endosomal Vesicle Trafficking · correlation 0.95
- mTOR Lysosomal Sensing · correlation 0.93
- Arp2/3 Actin Branching · correlation 0.90
- Epithelial Junction Integrity · correlation 0.90
- Senescent Stress Signaling · correlation 0.90
- Integrin Adhesion Signaling · correlation 0.89
- Nuclear Receptor Signaling · correlation 0.88
- Junction Cytoskeletal Remodeling · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.