SOX7 — SRY-box transcription factor 7
SOX7 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SOX7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Notch TGF-β Endothelial endothelial development | ARF6, ARL4C, C16orf87, CCNL1, CLK1, DEDD2, ELOC, GPBP1 +11 more | View in SCUBA |
| Pericytes | Vascular Identity TFs Developmental | CCDC85A, EXOC6, GIPC2, HHEX, MCTP1, SLC16A14, THSD7A, TSPAN7 | View in SCUBA |
About the gene
| Chromosome | 8: 10723768-10730511 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.