HHEX — Hematopoietically expressed homeobox
HHEX belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HHEX's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell antigen presentation B cell maturation | APBB1IP, BMP2K, BTN2A2, CIITA, CYTH4, EVL, MS4A1, SLC35D2 +6 more | View in SCUBA |
| Endothelial | Arterial EC Identity Endothelial cell development | ADAM23, AGPAT2, CLDN5, ECHDC2, GOLGA8B, LY6E, NDN, PERP +1 more | View in SCUBA |
| Macrophages | Innate Antiviral Sensing Innate immunity | ADA2, ADPRH, ALDH9A1, APOBEC3C, BST2, C2, CAT, CD4 +26 more | View in SCUBA |
| Pericytes | Vascular Identity TFs Developmental | CCDC85A, EXOC6, GIPC2, MCTP1, SLC16A14, SOX7, THSD7A, TSPAN7 | View in SCUBA |
About the gene
| Synonyms | HEX, HOX11L-PEN, PRHX |
|---|---|
| Chromosome | 10: 92689955-92695647 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Developmental protein, DNA-binding, Repressor |
| Biological process | Differentiation, Transcription, Transcription regulation, Wnt signaling pathway |
Function
Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1. Establishes anterior identity at two levels; acts early to enhance canonical WNT- signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). Inhibits EIF4E-mediated mRNA nuclear export. May play a role in hematopoietic differentiation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.