Arterial EC Homeostasis
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 19 genes have a known function matching the annotation |
Why this annotation
The module is dominated by five GIMAP family members (GIMAP1, GIMAP4, GIMAP6, GIMAP7, GIMAP8), GTPases classically associated with lymphocyte survival but also reported in arterial endothelial cells. Co-expressed genes include BMX (Btk-family kinase, a known arterial EC marker), SERPING1 (C1-inhibitor, expressed in liver and ECs), GAS6 (TAM receptor ligand, expressed in ECs), APOL3 (apolipoprotein, EC-expressed), and GABARAPL1 (autophagy). The module significantly decreases with UC inflammation and recovers with remission, consistent with a homeostatic arterial EC program suppressed during active disease. PIK3IP1 (PI3K inhibitor) and NFIX (transcription factor) support a quiescent/anti-proliferative state. The uniform distribution across subsets and EC-relevant co-expressed genes argue against pure T-cell contamination. Neighbor M36 shares the same inflammation-suppressed pattern, reinforcing a homeostatic EC neighborhood.
Genes
APOL3, BMX, EXOC6, FAXDC2, FTH1, GABARAPL1, GAS6, GIMAP1, GIMAP4, GIMAP6, GIMAP7, GIMAP8, METTL7A, NFIX, PIK3IP1, SERPING1, SSBP2, TMEM140, YPEL3
Most correlated modules
- Arterial EC Identity · correlation 0.63
- Quiescent EC Identity · correlation 0.62
- MHC Class I Presentation · correlation 0.61
- NF-κB Stress Signaling · correlation 0.59
- YAP Mechanotransduction · correlation 0.58
- Type I Interferon Response · correlation 0.55
- NF-kB Chromatin Regulation · correlation 0.52
- Type I Interferon · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.