Lysosomal Autophagy Program
Gene co-expression module in Endothelial
| Category | Stress |
|---|---|
| Genes | 13 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include AKR1A1 (aldo-keto reductase, oxidative stress/detoxification), CFI (complement factor I, immune regulation), MDH1 (malate dehydrogenase, TCA cycle), STAB1 (stabilin-1, scavenger receptor expressed in sinusoidal/anti-inflammatory endothelium), GNS (glucosamine-6-sulfatase, lysosomal), EBP (emopamil-binding protein, cholesterol biosynthesis), CD63 (lysosomal membrane protein), MAP1LC3A (autophagy), ABCD4 (peroxisomal ABC transporter). The module is upregulated in inflammation. STAB1 is a marker of anti-inflammatory/scavenger endothelium. CD63, MAP1LC3A, GNS, and ABCD4 suggest lysosomal/autophagic activity. AKR1A1 and EBP suggest metabolic/redox activity. The combination points to a lysosomal-autophagic metabolic program in endothelial cells.
Genes
ABCD4, AKR1A1, ASPH, CD63, CFI, EBP, GNS, MAP1LC3A, MDH1, NDUFA2, STAB1, SUMO3, TMEM54
Most correlated modules
- Leukocyte Recruitment Signaling · correlation 0.88
- Inflammatory Endothelial Activation · correlation 0.86
- p53 Stress Response · correlation 0.84
- Inflammatory Stress Response · correlation 0.83
- Angiogenic Metabolic Adaptation · correlation 0.82
- Mitochondrial Oxidative Stress · correlation 0.81
- Complement Innate Immune · correlation 0.81
- Oxidative Phosphorylation · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.