GPAT3 — Glycerol-3-phosphate acyltransferase 3
GPAT3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GPAT3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | NRF2 Oxidative Stress Stress | ACOT9, AHRR, ARMC9, BASP1, CARD19, CCDC71L, CD226, CLDND1 +27 more | View in SCUBA |
| Monocytes | Inflammatory Metabolic Reprogramming Inflammatory | ACTN1, ADAM8, DGAT2, EAF1, MCTP2, PTPN7, SLC25A37, SLC2A3 | View in SCUBA |
| Neutrophils | Specific Granule Release Degranulation | BMX, CA4, CKAP4, CLEC4D, KBTBD7, MMP9, VIM |
About the gene
| Synonyms | AGPAT10, AGPAT9, HMFN0839, LPAAT-theta, MAG1, MGC11324 |
|---|---|
| Chromosome | 4: 83535914-83605875 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Acyltransferase, Transferase |
| Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Function
Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone. Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Protects cells against lipotoxicity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.