GPR108 — G protein-coupled receptor 108
GPR108 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GPR108's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Oxidative phosphorylation Mitochondrial & OxPhos | ACADVL, CHMP1A, COX14, EIF2AK1, EML2, ETFA, NDUFA8, PARP1 +12 more | View in SCUBA |
| Innate lymphoid cells | NK Receptor Signaling Cytotoxicity | B2M, CD48, CLEC2B, DCK, FCER1G, FKBP11, HLA-A, HLA-B +12 more | View in SCUBA |
| Macrophages | Glycolytic Redox Metabolism Lipid metabolism | AGPAT2, ANXA5, ATP6V1F, BCKDK, BRI3, C1orf122, CLIC1, ELOC +18 more | View in SCUBA |
About the gene
| Synonyms | LUSTR2 |
|---|---|
| Chromosome | 19: 6729914-6737580 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Host-virus interaction |
Function
May play a role in intracellular immune modulation by activating NF-kappaB response and attenuating Toll-like-receptor response. (Microbial infection) Plays an essential function in adeno- associated virus (AAV) transduction across multiple serotypes except AAV5. May play a critical role in mediating the endosomal virus escape or in the AAV virions trafficking from endosomes to the nucleus
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.