GPR155 — G protein-coupled receptor 155
GPR155 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GPR155's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Naive/Memory CD8 T cell maturation | C1orf162, CD48, CD55, EEF1B2, IL7R, MATK, MYBL1, NACA +3 more | View in SCUBA |
| Macrophages | Macrophage Identity Innate immunity | CCDC88B, CSF1R, CYP4V2, CYSLTR1, EVL, FAM53B, FOXRED2, GATM +15 more | View in SCUBA |
| Monocytes | DNA Damage Response Stress | AGPAT5, ATM, CALM2, DCAF7, FAM13A, MEF2C, NLN, NSL1 +4 more | View in SCUBA |
About the gene
| Synonyms | DEP.7, DEPDC3, FLJ31819, PGR22 |
|---|---|
| Chromosome | 2: 174431571-174487094 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
Function
Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway. Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disruption of the interaction between the GATOR1 and KICSTOR complexes and promotion of mTORC1 signaling. Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition. Binds indole-3-acetic acid and may play a role in tryptophan metabolism.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.