MATK — Megakaryocyte-associated tyrosine kinase

MATK belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

MATK's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Cytotoxic Effector CD4 Cytotoxicity	ADAM8, ADRB2, CCL5, CHD9, DPP4, HIC1, HOPX, IFIT2 +13 more	View in SCUBA
CD8⁺ T cells	Naive/Memory CD8 T cell maturation	C1orf162, CD48, CD55, EEF1B2, GPR155, IL7R, MYBL1, NACA +3 more	View in SCUBA
Gamma-delta T cells	TCR Proximal Signaling TCR Signaling	ADGRG5, BIN2, C11orf21, C12orf75, CD300A, FGR, GPSM3, LAT +11 more
Innate lymphoid cells	NK Homing Circulating Homing & TEM	ADD3, ANXA1, APOBEC3G, C16orf54, C1orf162, CAPG, CASP4, CAST +37 more	View in SCUBA
Macrophages	SPP1 Tissue Remodeling ECM remodeling	BST1, CD52, CHI3L1, CHIT1, CSF1, FBP1, FGR, FN1 +19 more	View in SCUBA
Mucosal-associated invariant T cell	Cytoskeletal Remodeling Migration migration & adhesion	ADAM8, BIN2, C11orf21, CAPN1, CAPN2, CD52, CDC25B, CNN2 +14 more

About the gene

Synonyms	CHK, CTK, DKFZp434N1212, HHYLTK, HYL, HYLTK, Lsk, MGC1708, MGC2101
Chromosome	19: 3777970-3802129
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Enzymes, Predicted intracellular proteins
Molecular function	Kinase, Transferase, Tyrosine-protein kinase

Function

Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC- family members in brain by specifically phosphorylating their C- terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T- cell proliferation

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.