GRAP — GRB2 related adaptor protein
GRAP belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GRAP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mixed Metabolic Ambient Technical artifact | DPYD, ENO2, FABP6, FCGRT, SMURF2, SPINK2, SYNJ2BP, TNFRSF10B +1 more | View in SCUBA |
| Endothelial | Inflammatory Angiogenesis ECM remodeling | ADM, APOD, CHST15, CMTM3, GPIHBP1, HOMER3, LOX, MYH10 +7 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Valve Formation Valve formation | A2M, CD34, CISD1, FAM89A, FHL3, FSCN1, GJC2, HTRA1 +5 more | View in SCUBA |
About the gene
| Chromosome | 17: 19020656-19047011 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
Function
Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.