LOX — Lysyl oxidase
LOX belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LOX's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Angiogenesis ECM remodeling | ADM, APOD, CHST15, CMTM3, GPIHBP1, GRAP, HOMER3, MYH10 +7 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Valve Formation Valve formation | A2M, CD34, CISD1, FAM89A, FHL3, FSCN1, GJC2, GRAP +5 more | View in SCUBA |
About the gene
| Chromosome | 5: 122063195-122078413 |
|---|---|
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Oxidoreductase |
Function
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.