Inflammatory Angiogenesis
Gene co-expression module in Endothelial
| Category | ECM remodeling |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include ADM (adrenomedullin, potent vasodilatory peptide and lymphangiogenic factor), LOX (lysyl oxidase, ECM crosslinking and vascular remodeling), CHST15 (heparan sulfate sulfotransferase, ECM modification), SMTN (smoothelin, pericyte/vascular smooth muscle marker), WFS1 (wolframin, ER stress/calcium homeostasis), GPIHBP1 (GPI-anchored protein on capillary ECs for lipoprotein transport), and USP31 (deubiquitinase). ADM+LOX+CHST15 point to vascular ECM remodeling and angiogenic signaling. Upregulation in CD inflammation is consistent with inflammatory angiogenesis/remodeling. The module captures an EC response involving vasoactive peptide signaling and ECM modification.
Genes
ADM, APOD, CHST15, CMTM3, GPIHBP1, GRAP, HOMER3, LOX, MYH10, N4BP3, PRND, RNF152, SLC38A1, SMTN, USP31, WFS1
Most correlated modules
- EC Cytoskeletal Scaffold · correlation 0.76
- Actomyosin Contractility · correlation 0.72
- Arterial EC Identity · correlation 0.68
- Venous EC Identity · correlation 0.68
- Inflammatory EC Activation · correlation 0.59
- Inflammatory ECM Remodeling · correlation 0.58
- Venous EC Identity · correlation 0.56
- CXCL12 Angiogenic Chemotaxis · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.