Lymphatic Valve Formation
Gene co-expression module in Lymphatic endothelial
| Category | Valve formation |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include HTRA1 (serine protease, ECM remodeling and TGF-β regulation), FSCN1 (fascin, actin bundling for filopodia/migration), LOX (lysyl oxidase, ECM crosslinking/stiffening), A2M (alpha-2-macroglobulin, broad protease inhibitor), GJC2 (connexin 47, specifically mutated in lymphedema and expressed in lymphatic valves), CD34 (endothelial/progenitor marker), TM4SF18 (transmembrane 4 superfamily), and OLFML2A (olfactomedin-like, ECM). GJC2 is a hallmark of lymphatic valve endothelial cells. FSCN1 and LOX suggest active ECM remodeling and cytoskeletal reorganization. HTRA1 regulates TGF-β and ECM. This module is consistent with a lymphatic valve formation or tip-cell/sprouting program, with GJC2 as the key discriminating gene.
Genes
A2M, CD34, CISD1, FAM89A, FHL3, FSCN1, GJC2, GRAP, HTRA1, KCTD17, LOX, LRRN4CL, OLFML2A, TM4SF18
Most correlated modules
- Lymphatic Vascular Stability · correlation 0.86
- Lymphatic EC Identity · correlation 0.78
- Oxidative Stress Protection · correlation 0.78
- ECM Remodeling TGFb · correlation 0.75
- Septin Cytoskeleton · correlation 0.72
- Anticoagulant Barrier · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.