MYH10 — Myosin heavy chain 10
MYH10 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MYH10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Angiogenesis ECM remodeling | ADM, APOD, CHST15, CMTM3, GPIHBP1, GRAP, HOMER3, LOX +7 more | View in SCUBA |
| Hematopoietic progenitor cells | Erythroid Differentiation Erythropoietic | DHRS11, DNAJC6, EPOR, FHL2, GATA1, HBD, KLF1, LXN +5 more | |
| Lymphatic endothelial | Lymphangiogenesis ECM endothelial development | ARHGAP18, CEP68, CFI, DIPK2B, EGFL7, ELK3, ELN, FLT4 +10 more | View in SCUBA |
About the gene
| Synonyms | NMMHCB |
|---|---|
| Chromosome | 17: 8474207-8631376 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Actin-binding, Calmodulin-binding, Host cell receptor for virus entry, Motor protein, Myosin, Receptor |
| Biological process | Cell adhesion, Cell shape |
Function
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.