GSTA1 — Glutathione S-transferase alpha 1
GSTA1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GSTA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Carbohydrate Digestion/Detox Nutrient metabolism | CBR1, CMBL, DDC, HADHB, KBTBD11, MAOA, PEBP1, SI +1 more | View in SCUBA |
| Goblet cells | BMP Signaling Response Epithelial development | CAMK2N1, CCND2, EIF4A2, GSTA4, ID2, ID3, PDK4, ZBTB10 | View in SCUBA |
About the gene
| Chromosome | 6: 52791371-52803860 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Isomerase, Oxidoreductase, Peroxidase, Transferase |
| Biological process | Lipid metabolism |
Function
Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene- 3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)- hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.