Carbohydrate Digestion/Detox
Gene co-expression module in Enterocytes
| Category | Nutrient metabolism |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
SI (sucrase-isomaltase) and TKFC (fructose metabolism) mark mature small-intestine-like absorptive enterocytes. Detoxification genes (CBR1, GSTA1, CMBL, MAOA, DDC) point to xenobiotic and amine metabolism, and HADHB adds fatty acid oxidation. Together these suggest carbohydrate absorption with detox in mature enterocytes. It overlaps with the M24 detox program.
Genes
CBR1, CMBL, DDC, GSTA1, HADHB, KBTBD11, MAOA, PEBP1, SI, TKFC
Most correlated modules
- Xenobiotic Detoxification · correlation 0.94
- Enterocyte Ion/Nutrient Transport · correlation 0.93
- PGC1A/ERRG metabolic program · correlation 0.90
- Gluconeogenesis/fructose metabolism · correlation 0.88
- Lipid/bile acid uptake · correlation 0.82
- PPARA/FXR fatty acid oxidation · correlation 0.78
- Brush-border nutrient uptake · correlation 0.77
- Mitochondrial Energy Metabolism · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.