EREG — Epiregulin
EREG belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EREG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Notch Secretory Specification Epithelial development | EDN1, FKBP1A, GPRC5C, HES4, HES5, MYC, NOTCH2, PDGFA +4 more | View in SCUBA |
| Hematopoietic progenitor cells | General Metabolic Housekeeping Housekeeping | ACSM3, DTD1, FXN, NAA38, SERPINE2, SLC39A3, SLC39A8 | |
| Innate lymphoid cells | ILC3 identity Differentiation | ABCC1, BCL6, CCND3, CELF2, CHKB, DNAAF2, ENSG00000285976, FKBP5 +31 more | View in SCUBA |
| Monocytes | NLRP3 Inflammasome Activation Innate immunity | ACSL1, BASP1, CCDC71L, CCL20, F3, FAM107B, LRG1, NLRP3 +3 more | View in SCUBA |
About the gene
| Synonyms | ER |
|---|---|
| Chromosome | 4: 74365145-74388749 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Human disease related genes, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Developmental protein, Growth factor, Mitogen |
| Biological process | Angiogenesis, Differentiation |
Function
Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.