ILC3 identity
Gene co-expression module in Innate lymphoid cells
| Category | Differentiation |
|---|---|
| Genes | 40 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 20 genes have a known function matching the annotation |
Why this annotation
The module is dominated by H1 histone variants (H1-10, H1-3, H1-4, H1-2) and chromatin remodeling genes (SMARCA2), alongside glucocorticoid-responsive genes (FKBP5, KLF9) and RUNX2. Nearly all genes show strong enrichment in SLO_ILC3 (up to 11.7x for VSTM2L), a cell lineage distinct from NK cells. The moderate coherence and uniformly weak gene membership scores, combined with the consistent ILC3 enrichment, indicate this module reflects ILC3 contamination rather than a bona fide NK program. The histone H1 variants and SMARCA2 may reflect ILC3-specific chromatin accessibility states.
Genes
ABCC1, BCL6, CCND3, CELF2, CHKB, DNAAF2, ENSG00000285976, EREG, FKBP5, FOXN3, H1-10, H1-2, H1-3, H1-4, HNRNPL, IL18, IRAK3, KLF9, LSR, MYH9, PARP8, PNPLA2, RASGRP2, RESF1, RNF130, RUNX2, SCPEP1, SESN1, SMARCA2, SNX9, SPON2, STING1, TAMALIN, TARS3, TGFBR2, TLE5, TMX4, TXNIP, USP53, VSTM2L
Most correlated modules
- ILC3 identity · correlation 0.58
- Inflammasome Activation · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.