H2AJ — H2A.J histone
H2AJ belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
H2AJ's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | mRNA Translation RNA processing & translation | ABHD14B, ARHGDIA, CD2BP2, EEF2, EIF3L, GYPC, HNRNPA0, HNRNPDL +6 more | View in SCUBA |
| Monocytes | Histone Chromatin Remodeling Housekeeping | CTSD, H1-10, H1-2, H1-3, H1-4, H4C3, HMGB2, HOXA9 | View in SCUBA |
| Natural Killer cells | Housekeeping Mixed DNA regulation & transcription | ATP6V0C, ENSG00000285976, H3-3B, MARCHF3, NCBP2AS2, PNPLA2, PRXL2C, TARS3 +1 more | View in SCUBA |
About the gene
| Synonyms | FLJ10903, H2AFJ, MGC921 |
|---|---|
| Chromosome | 12: 14774405-14778002 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.