REXO2 — RNA exonuclease 2
REXO2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
REXO2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Inflammatory activation Immune regulation | ACP5, B2M, CALCOCO1, CCNG2, CHST11, CORO1A, HLA-A, IL32 +10 more | View in SCUBA |
| Endothelial | Redox Stress Response Stress | APEX1, ATP5F1E, ATP5MC1, CDC42EP5, EIF4EBP1, EPS8L1, MAGED1, MCFD2 +7 more | View in SCUBA |
| Hematopoietic progenitor cells | Erythroid Heme Synthesis Erythropoietic | BLVRB, HBQ1, HES6, MPC2, MPST, SMIM10, TMEM14B, TMEM14C +2 more | |
| Pericytes | ER Stress Response Stress | ARF4, HSPA5, LDHA, PDLIM1, RAP1B, SEC61G, SELENOS, SNX6 | View in SCUBA |
| Smooth muscle cells | Mesenchymal Adhesion Program Migration & adhesion | ANTXR1, BAG2, CDH11, COL12A1, CTSB, FHL3, FSTL3, HEPH +6 more | View in SCUBA |
About the gene
| Synonyms | CGI-114, DKFZP566E144, SFN |
|---|---|
| Chromosome | 11: 114439435-114450279 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Exonuclease, Hydrolase, Nuclease |
Function
3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development (By similarity). 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.