TMEM14B — Transmembrane protein 14B
TMEM14B belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM14B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Oxidative phosphorylation Mitochondrial & OxPhos | ACADVL, CHMP1A, COX14, EIF2AK1, EML2, ETFA, GPR108, NDUFA8 +12 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial Ribosome Mitochondrial & OxPhos | APEX1, APRT, EIF3M, EXOSC5, FAM162A, LSM7, MRPL24, MZT2A +10 more | |
| Hematopoietic progenitor cells | Erythroid Heme Synthesis Erythropoietic | BLVRB, HBQ1, HES6, MPC2, MPST, REXO2, SMIM10, TMEM14C +2 more | |
| Macrophages | Spliceosomal snRNP Cell cycle | ANAPC11, BANF1, CCDC25, CCT8, ERH, FIBP, FKBP3, GLRX5 +30 more | View in SCUBA |
About the gene
| Synonyms | MGC1223 |
|---|---|
| Chromosome | 6: 10747759-10852753 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Molecular function | Developmental protein |
| Biological process | Neurogenesis |
Function
Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.