Erythroid Heme Synthesis
Gene co-expression module in Hematopoietic progenitor cells
| Category | Erythropoietic |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
TMEM14C and TMEM14B are inner mitochondrial membrane transporters essential for protoporphyrin IX import during erythroid heme synthesis. UROD (uroporphyrinogen decarboxylase) is a heme biosynthesis enzyme. BLVRB (biliverdin reductase B) is expressed in erythroid progenitors. HBQ1 is an embryonic/fetal hemoglobin subunit. HES6 is an erythroid transcription regulator. SMIM10 is erythroid-specific. MPC2 (mitochondrial pyruvate carrier) supports erythroid metabolism. This module represents early erythroid progenitor / heme biosynthesis program within the HPC compartment.
Genes
BLVRB, HBQ1, HES6, MPC2, MPST, REXO2, SMIM10, TMEM14B, TMEM14C, TST, UROD
Most correlated modules
- Mature Erythrocyte · correlation 0.79
- Nucleotide Metabolism · correlation 0.76
- Chaperonin TRiC Complex · correlation 0.74
- Proteostasis & OxPhos · correlation 0.74
- RNA Processing Housekeeping · correlation 0.72
- Ribosome Biogenesis · correlation 0.69
- DNA Damage Repair · correlation 0.68
- General Metabolic Housekeeping · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.