HHLA2 — HERV-H LTR-associating 2
HHLA2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HHLA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Brush-border enterocyte Absorption | CD2AP, CEACAM20, ERBIN, GK, MAN1A1, MAPK6, NCKAP5, SLC36A1 | View in SCUBA |
About the gene
| Synonyms | B7-H5, B7-H7, B7H7, B7y |
|---|---|
| Chromosome | 3: 108296529-108378285 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
Function
Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.