Brush-border enterocyte
Gene co-expression module in Enterocytes
| Category | Absorption |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
SLC36A1 (PAT1 amino acid transporter), CEACAM20 (brush-border microvillar protein), GK (glycerol kinase), MAN1A1 and HHLA2 are features of mature absorptive enterocytes. ERBIN and CD2AP provide basolateral/junctional scaffolding. The module co-varies with M48, supporting an absorptive enterocyte identity.
Genes
CD2AP, CEACAM20, ERBIN, GK, HHLA2, MAN1A1, MAPK6, NCKAP5, SLC36A1
Most correlated modules
- Amino acid absorption · correlation 0.91
- Epithelial junction polarity · correlation 0.91
- Enterocyte fatty-acid catabolism · correlation 0.90
- Surface colonocyte lipid-droplet · correlation 0.90
- ER-autophagy homeostasis · correlation 0.88
- Apical Na+/H+ transport · correlation 0.88
- Junctional Hippo/TGF-beta signaling · correlation 0.87
- Colonocyte differentiation signaling · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.