HSD17B2 — Hydroxysteroid 17-beta dehydrogenase 2
HSD17B2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HSD17B2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Mature colonocyte absorptive Absorption | ADI1, BRI3, BTG1, CAMK2N1, CTSZ, FXYD3, GUCA2A, GUCA2B +9 more | View in SCUBA |
| Fibroblasts | WNT-modulating Fibroblast Developmental | CIB2, COL4A5, DMKN, F3, FIP1L1, FRZB, GPSM3, INSC +9 more | View in SCUBA |
About the gene
| Synonyms | HSD17, SDR9C2 |
|---|---|
| Chromosome | 16: 82035004-82098534 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis |
Function
Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.