Mature colonocyte absorptive
Gene co-expression module in Enterocytes
| Category | Absorption |
|---|---|
| Genes | 18 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 18 genes have a known function matching the annotation |
Why this annotation
GUCA2A, GUCA2B, PRR15L, FXYD3, TM4SF5, HSD17B2, CAMK2N1, ADI1 and CTSZ mark mature absorptive colonocytes. GUCA2A/B are guanylin peptides that regulate ion and fluid transport. Together this is a mature absorptive colonocyte identity program.
Genes
ADI1, BRI3, BTG1, CAMK2N1, CTSZ, FXYD3, GUCA2A, GUCA2B, HSD17B2, JUND, OAZ1, PPDPF, PRR15L, SRI, TM4SF5, TMEM59, TMSB4X, VPS35
Most correlated modules
- Lysosomal/ferritin housekeeping · correlation 0.79
- High-abundance housekeeping · correlation 0.55
- Translational repression · correlation 0.55
- Metallothionein metal response · correlation 0.54
- Surface colonocyte transport · correlation 0.45
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.