ADI1 — Acireductone dioxygenase 1
ADI1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADI1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Chromatin Regulation DNA/chromatin regulation | ASXL2, BTG3, CASP8, CHD3, CTSS, CWF19L2, DENND2D, DNTTIP2 +17 more | View in SCUBA |
| Endothelial | Inflammatory Stress Response Inflammation | APLN, ARL6IP1, ARL6IP4, CCDC88A, DAP, GPR68, HEBP2, ITGAV +11 more | View in SCUBA |
| Enterocytes | Mature colonocyte absorptive Absorption | BRI3, BTG1, CAMK2N1, CTSZ, FXYD3, GUCA2A, GUCA2B, HSD17B2 +9 more | View in SCUBA |
| Fibroblasts | Complement-secreting Fibroblast Immune interaction | ARL6IP5, C1R, C2, CYB5A, FCGRT, FTH1, FTL, GPX4 +9 more | View in SCUBA |
| Innate lymphoid cells | Pyruvate Metabolism Metabolism | ABCB1, ARID1B, ATF7IP2, CFAP298, EIF2AK2, HNRNPH3, MINDY2, MPC2 +10 more | View in SCUBA |
| Macrophages | Protein Homeostasis Mixed Housekeeping | ABRACL, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, CLTA, COPS9 +33 more | View in SCUBA |
About the gene
| Synonyms | APL1, ARD, FLJ10913, HMFT1638, MTCBP-1, mtnD, SIPL |
|---|---|
| Chromosome | 2: 3497366-3519531 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Dioxygenase, Oxidoreductase |
| Biological process | Amino-acid biosynthesis, Methionine biosynthesis |
Function
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site (By similarity). Fe- containing acireductone dioxygenase (Fe-ARD) produces formate and 2- keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni- containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.