IFT27 — Intraflagellar transport 27
IFT27 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IFT27's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | DNA Repair Housekeeping Housekeeping | ANAPC16, CCDC85B, CDIP1, CKLF, COTL1, DNAJC4, ECH1, ERCC1 +10 more | |
| Innate lymphoid cells | Mitochondrial OxPhos Biogenesis Mitochondrial & OxPhos | AP1S1, ATOX1, ATP5ME, ATP5MF, C1QBP, CNIH1, CYC1, ERH +22 more | View in SCUBA |
About the gene
| Synonyms | BBS19, FAP156, RABL4, RAYL |
|---|---|
| Chromosome | 22: 36758202-36776256 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters |
| Biological process | Differentiation, Protein transport, Spermatogenesis, Transport |
Function
Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6. Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6. Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.