Mitochondrial OxPhos Biogenesis
Gene co-expression module in Innate lymphoid cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 31 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 31 genes have a known function matching the annotation |
Why this annotation
The module contains multiple mitochondrial complex I subunits (NDUFS6, NDUFA2, NDUFAB1), complex III (CYC1), ATP synthase (ATP5MF), and mitochondrial import machinery (TIMM8B). MRPL42 and MRPL11 are mitochondrial ribosomal proteins. HSD17B10 is a mitochondrial enzyme. C1QBP is a mitochondrial matrix protein involved in mitochondrial translation. ATOX1 is a copper chaperone relevant to mitochondrial function. ERH, RANBP1, SNRPE, PUF60 are RNA processing/splicing factors that may co-regulate mitochondrial biogenesis. PSMA4 is a proteasome subunit. NME1 is a nucleoside diphosphate kinase. The dominant signal is mitochondrial OxPhos and biogenesis, with some RNA processing admixture. ILC1 enrichment is consistent across all genes. Neighbor context: M71, M96, M53, M88 all share mitochondrial/metabolic themes, supporting a coherent OxPhos neighborhood.
Genes
AP1S1, ATOX1, ATP5ME, ATP5MF, C1QBP, CNIH1, CYC1, ERH, HSD17B10, IDH3B, IFT27, LAGE3, MRPL11, MRPL42, NDUFA2, NDUFA3, NDUFAB1, NDUFS6, NME1, POLR2I, PSMA4, PUF60, RANBP1, RHOG, RNF181, SCP2, SNRPE, TIMM8B, VDAC2, VPS25, ZNF580
Most correlated modules
- Glycolysis & OxPhos · correlation 0.96
- Proteasome & COPI Trafficking · correlation 0.96
- Mitochondrial OxPhos · correlation 0.96
- mTOR Metabolic Stress · correlation 0.95
- Lipid & Isoprenoid Metabolism · correlation 0.95
- Mitochondrial Metabolism · correlation 0.95
- Mitochondrial Lysosomal Housekeeping · correlation 0.95
- Mixed Proteostasis Metabolism · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.