ERCC1 — ERCC excision repair 1, endonuclease non-catalytic subunit
ERCC1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ERCC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Respiratory chain assembly Mitochondrial & OxPhos | COA4, COA6, CYC1, EBNA1BP2, POLR2E, PRELID3B, PSMD3, VMA21 | View in SCUBA |
| Gamma-delta T cells | DNA Repair Housekeeping Housekeeping | ANAPC16, CCDC85B, CDIP1, CKLF, COTL1, DNAJC4, ECH1, IFT27 +10 more | |
| Innate lymphoid cells | Mitochondrial Metabolism Mitochondrial & OxPhos | ACTR10, ANP32A, APOL3, ATP6V1E1, ECHS1, ETFB, GLRX3, HIGD1A +12 more | View in SCUBA |
| Macrophages | Translation Initiation Housekeeping | AKR1B1, CAMLG, CAPZB, EEF1D, EEF2, EID1, EIF3D, EIF3E +26 more | View in SCUBA |
About the gene
| Synonyms | RAD10 |
|---|---|
| Chromosome | 19: 45407334-45478828 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | DNA damage, DNA repair |
Function
Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. Not functional in the nucleotide excision repair pathway. Not functional in the nucleotide excision repair pathway. Not functional in the nucleotide excision repair pathway
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.