MGLL — Monoglyceride lipase
MGLL belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MGLL's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | CA4, CABP1, CD36, FABP5, FMNL2, IGFBP6, ISLR, LNX1 +6 more | View in SCUBA |
| Fibroblasts | Myofibroblast Subtype Wound healing | EDNRB, FOXL1, HACD4, KCTD9, PDGFD, POSTN, TSPAN33, ZEB1 | View in SCUBA |
| Gamma-delta T cells | Basal Lipid Metabolism Housekeeping | ACOT7, ADCY3, AHCY, CLN6, DENND6B, FANCL, MPST, NUDT8 +6 more | |
| Smooth muscle cells | Lipid Kinase Signaling Housekeeping | ABTB1, ARRDC4, CACNA1H, CBX7, CX3CL1, DGKD, DNTTIP2, FCHSD2 +10 more | View in SCUBA |
About the gene
| Synonyms | HU-K5, MAGL, MGL |
|---|---|
| Chromosome | 3: 127689062-128052190 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Serine esterase |
| Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid degradation, Lipid metabolism |
Function
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2- arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.