CA4 — Carbonic anhydrase 4
CA4 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CA4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | CABP1, CD36, FABP5, FMNL2, IGFBP6, ISLR, LNX1, MGLL +6 more | View in SCUBA |
| Enterocytes | Surface colonocyte transport Absorption | CD46, CITED1, CLCN1, DOCK4, GSN, HSPB1, ITM2C, LYPD8 +4 more | View in SCUBA |
| Neutrophils | Specific Granule Release Degranulation | BMX, CKAP4, CLEC4D, GPAT3, KBTBD7, MMP9, VIM | |
| Pericytes | Pericyte Vascular Identity Developmental | AHR, ARHGAP29, CD46, MEF2C, MYO6, NOTCH1, PDE1C, PLXND1 +10 more | View in SCUBA |
About the gene
| Synonyms | CAIV, Car4, RP17 |
|---|---|
| Chromosome | 17: 60149942-60170899 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Lyase |
Function
Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.