IL1RN — Interleukin 1 receptor antagonist
IL1RN belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL1RN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | NF-κB Inflammatory Activation Inflammatory | ADM, CCL2, CCL20, CCL7, CLEC4E, CXCL1, CXCL2, CXCL3 +19 more | View in SCUBA |
| Monocytes | NF-κB Counter-regulation Inflammatory | ABL2, C15orf48, CD274, GPR84, RHOH, TNFAIP8, TNIP3 | View in SCUBA |
| Neutrophils | Inflammasome IL-1 Response Cytokine & chemokine secretion | CSRNP1, EGR3, G0S2, IER3, IFRD1, IL1B, IVNS1ABP, LPCAT1 +5 more |
About the gene
| Synonyms | ICIL-1RA, IL-1RN, IL1F3, IL1RA, IRAP, MGC10430 |
|---|---|
| Chromosome | 2: 113099315-113134016 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
Function
Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.