IL34 — Interleukin 34
IL34 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL34's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Leukocyte Recruitment Signaling Inflammation | BIRC3, CELSR1, CSF2RB, HAPLN3, HSD3B7, IL7R, LTF, OLFM1 +6 more | View in SCUBA |
| Fibroblasts | Homeostatic Fibroblast Identity ECM production | ADGRL2, C1S, DCN, DKK3, DPYSL2, IL6ST, LUM, PARM1 +6 more | View in SCUBA |
About the gene
| Synonyms | C16orf77, IL-34, MGC34647 |
|---|---|
| Chromosome | 16: 70579895-70660682 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Cytokine, Growth factor |
| Biological process | Immunity, Inflammatory response, Innate immunity |
Function
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.