C1S — Complement C1s
C1S belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
C1S's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Complement Innate Immune Inflammation | C1R, CD47, CNDP2, COL5A2, CTSS, GRINA, GSDMD, LGALS9 +9 more | View in SCUBA |
| Fibroblasts | Homeostatic Fibroblast Identity ECM production | ADGRL2, DCN, DKK3, DPYSL2, IL34, IL6ST, LUM, PARM1 +6 more | View in SCUBA |
| Glial cells | MHC-I Antigen Presentation Inflammation | B2M, BTN3A2, C1R, CST3, HLA-A, HLA-B, HLA-C, IFI27 +4 more | View in SCUBA |
| Smooth muscle cells | Matrix-integrin interaction ECM remodeling | EML1, FBN1, ITGA1, ITGAV, LRP1, P4HA2, VMP1 | View in SCUBA |
About the gene
| Chromosome | 12: 6988259-7071032 |
|---|---|
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Protease, Serine protease |
| Biological process | Complement pathway, Immunity, Innate immunity |
Function
Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1S is activated following association of the C1 complex with immunoglobulins (IgG or IgM) complexed with antigens to form antigen-antibody complexes on the surface of pathogens. C1S is cleaved and activated by C1R to generate C1s subcomponent heavy and light chains. C1s subcomponent light chain then cleaves and activates C2 and C4, the next components of the classical complement pathway. Serine protease component of the complement C1 complex, which catalyzes cleavage and activation of C2 and C4, the next components of the classical complement pathway. Also able to cleave C1 inhibitor (SERPING1) in vitro; additional evidence is however required to confirm this result in vivo. Also cleaves IGFBP5 and thereby inhibits the trophic effects of IGF1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.