OLFM1 — Olfactomedin 1
OLFM1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OLFM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Leukocyte Recruitment Signaling Inflammation | BIRC3, CELSR1, CSF2RB, HAPLN3, HSD3B7, IL34, IL7R, LTF +6 more | View in SCUBA |
| Lymphatic endothelial | Hypoxia HIF Response Stress | AKR1C1, AKR1C2, AKR1C3, ATP1A1, BNIP3, CARHSP1, CSRP2, CTSS +4 more | View in SCUBA |
About the gene
| Synonyms | AMY, NOE1, NOELIN, OlfA |
|---|---|
| Chromosome | 9: 135075422-135121180 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Transporters |
| Molecular function | Developmental protein |
Function
Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.