Leukocyte Recruitment Signaling
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes include SELP (P-selectin, leukocyte rolling), CSF2RB (GM-CSF/IL-3/IL-5 receptor β subunit), IL34 (myeloid cytokine), IL7R (lymphocyte cytokine receptor), BIRC3 (NF-κB anti-apoptotic target), PYCARD (ASC/inflammasome adaptor), and LTF (lactoferrin). Together these define an endothelial state of leukocyte recruitment via selectin-mediated adhesion combined with myeloid and lymphoid cytokine signaling. Strongly upregulated in both UC and CD inflammation and reversed in UC remission, consistent with active IBD endothelial activation. Neighbor M61 captures the upstream NF-κB transcriptional driver, while M108 represents the downstream cytokine receptor and adhesion effector arm.
Genes
BIRC3, CELSR1, CSF2RB, HAPLN3, HSD3B7, IL34, IL7R, LTF, OLFM1, PAPLN, PLA1A, PRCP, PYCARD, SELP, ZNF385D
Most correlated modules
- Lysosomal Autophagy Program · correlation 0.88
- Myeloid Contamination · correlation 0.87
- IL33 Alarmin Signaling · correlation 0.85
- Angiogenic Metabolic Adaptation · correlation 0.82
- Complement Innate Immune · correlation 0.81
- Venular Inflammatory Activation · correlation 0.81
- NF-κB Endothelial Activation · correlation 0.80
- Inflammatory Stress Response · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.