JADE2 — Jade family PHD finger 2
JADE2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
JADE2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | CD200 immunoregulation Immune regulation | B3GNT2, CAV1, CD200, CD79A, CH25H, CHGB, DUOX1, ELF2 +23 more | View in SCUBA |
| Gamma-delta T cells | Translation & Proteostasis RNA processing & translation | ARAP2, ATG13, BRPF1, CLINT1, CRKL, E2F3, EEF2, EIF2AK2 +15 more | |
| Mucosal-associated invariant T cell | T cell Activation Signaling TCR Signaling | AGAP2, ARHGAP45, CDK5RAP3, DNMT1, IL10RA, ITGAL, NBR1, PLCB2 +6 more |
About the gene
| Synonyms | JADE-2, KIAA0239, PHF15 |
|---|---|
| Chromosome | 5: 134524312-134583230 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A. Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.