NBR1 — NBR1 autophagy cargo receptor
NBR1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NBR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Membrane trafficking Housekeeping | BCL2, CLSTN1, GLB1, GTF2I, HPSE, HSDL2, LENG8, MBIP +19 more | View in SCUBA |
| Gamma-delta T cells | Actin Cytoskeletal Regulation Cytoskeletal | ACTR2, AP3B1, AP3M1, AZI2, CAPZA1, CEP250, CPSF3, DIDO1 +25 more | |
| Macrophages | Myeloid Innate Signaling Innate immunity | ADCY7, ARHGAP18, BMP2K, C3AR1, C6orf62, CD46, CD84, CLTC +34 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Activation Signaling TCR Signaling | AGAP2, ARHGAP45, CDK5RAP3, DNMT1, IL10RA, ITGAL, JADE2, PLCB2 +6 more |
About the gene
| Synonyms | 1A1-3B, CA125, KIAA0049, M17S2 |
|---|---|
| Chromosome | 17: 43170481-43211689 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Host-virus interaction |
Function
Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis. Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation. In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.