PLCB2 — Phospholipase C beta 2
PLCB2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLCB2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | TCR Activation Signaling TCR Signaling | ADCY7, ATP2B4, CYFIP2, DIAPH1, GK5, GLG1, ITGAL, NBEAL2 +4 more | |
| Macrophages | Macrophage Identity Innate immunity | CCDC88B, CSF1R, CYP4V2, CYSLTR1, EVL, FAM53B, FOXRED2, GATM +15 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Activation Signaling TCR Signaling | AGAP2, ARHGAP45, CDK5RAP3, DNMT1, IL10RA, ITGAL, JADE2, NBR1 +6 more |
About the gene
| Synonyms | FLJ38135 |
|---|---|
| Chromosome | 15: 40278176-40307935 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Transducer |
| Biological process | Lipid degradation, Lipid metabolism |
Function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein- coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.