T cell Activation Signaling
Gene co-expression module in Mucosal-associated invariant T cell
| Category | TCR Signaling |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
PLCG1 (phospholipase C-gamma, central TCR/BCR signaling), ITGAL (LFA-1 integrin, T cell adhesion and migration), IL10RA (IL-10 receptor, immune regulation), STAT6 (IL-4/IL-13 JAK-STAT signaling), PLCB2 (phospholipase C-beta), ARHGAP45 (RhoGAP, cytoskeletal regulation in lymphocytes), NBR1 (autophagy receptor), and DNMT1 (epigenetic maintenance) together suggest a T cell activation and immune regulatory signaling program. PLCG1 + ITGAL + IL10RA form a coherent T cell signaling/adhesion/regulation axis. Neighbor context with M4 (PI3K/calcineurin) supports a broader T cell activation signaling neighborhood.
Genes
AGAP2, ARHGAP45, CDK5RAP3, DNMT1, IL10RA, ITGAL, JADE2, NBR1, PLCB2, PLCG1, PSD4, RAB18, SLC20A1, STAT6, THRAP3
Most correlated modules
- IL-12 Cytotoxic Effector · correlation 0.88
- Nuclear-Cytoskeletal Organization · correlation 0.85
- SWI/SNF Chromatin Remodeling · correlation 0.85
- PI3K-Calcineurin Signaling · correlation 0.84
- Chromatin Complex Regulation · correlation 0.82
- Cytoskeletal Organization · correlation 0.80
- Endosomal Actin Organization · correlation 0.76
- Chromatin Maintenance State · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.