KCNMB1 — Potassium calcium-activated channel subfamily M regulatory beta subunit 1

KCNMB1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

KCNMB1's module in each cell type

Cell type	Module	Shares the module with
Fibroblasts	Smooth Muscle Identity Cytoskeletal	ACTG2, ALDH1B1, C3orf70, CNN1, FBXL22, HSD17B6, JPH2, KCNH2 +12 more	View in SCUBA
Smooth muscle cells	Contractile SMC phenotype Contractility	ACTN1, CNN1, DES, LBR, MYLK, PDLIM7, SLMAP, SORBS1 +1 more	View in SCUBA

About the gene

Synonyms	hslo-beta
Chromosome	5: 170374671-170389634
Predicted location	Membrane
Essential gene	No
Protein class	FDA approved drug targets, Predicted membrane proteins, Transporters
Molecular function	Ion channel
Biological process	Ion transport, Transport

Function

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.