SLMAP — Sarcolemma associated protein
SLMAP belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLMAP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Basal adhesion remodeling Migration & adhesion | EPB41L2, ETS2, FNDC3B, HERC4, ITGA6, NT5C2, SESTD1, SGMS1 +2 more | View in SCUBA |
| Fibroblasts | Smooth Muscle Identity Cytoskeletal | ACTG2, ALDH1B1, C3orf70, CNN1, FBXL22, HSD17B6, JPH2, KCNH2 +12 more | View in SCUBA |
| Gamma-delta T cells | Transcriptional Repressor Complex DNA/chromatin regulation | BAG1, CAB39, CLEC2B, EBP, FBXO31, GFI1, MAN1A1, MAP2K1 +14 more | |
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABCC1, ABR, ANKRD17, ARFGEF2, ARHGAP10, ARID2, ATAD2B, ATP9B +44 more | View in SCUBA |
| Neutrophils | JAK-MAPK Signaling Inflammatory | CELF2, ENTPD1, GIT2, JAK2, MAPK1, MBNL1, SPTLC2, TLE4 +1 more | |
| Smooth muscle cells | Contractile SMC phenotype Contractility | ACTN1, CNN1, DES, KCNMB1, LBR, MYLK, PDLIM7, SORBS1 +1 more | View in SCUBA |
About the gene
| Synonyms | KIAA1601, SLAP |
|---|---|
| Chromosome | 3: 57755450-57930003 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
Function
Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex. The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth. May play a role during myoblast fusion (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.