SORBS1 — Sorbin and SH3 domain containing 1
SORBS1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SORBS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Smooth Muscle Identity Cytoskeletal | ACTG2, ALDH1B1, C3orf70, CNN1, FBXL22, HSD17B6, JPH2, KCNH2 +12 more | View in SCUBA |
| Lymphatic endothelial | Collecting Lymphatic Identity migration & adhesion | CCDC141, EFNB2, EPB41, FBXO34, FGD6, GUCY1A1, ITGA6, MDFIC +13 more | View in SCUBA |
| Smooth muscle cells | Contractile SMC phenotype Contractility | ACTN1, CNN1, DES, KCNMB1, LBR, MYLK, PDLIM7, SLMAP +1 more | View in SCUBA |
About the gene
| Synonyms | CAP, FLJ12406, KIAA1296, ponsin, SH3D5, sh3p12 |
|---|---|
| Chromosome | 10: 95311771-95561414 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Transport |
Function
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.