KCNH2 — Potassium voltage-gated channel subfamily H member 2
KCNH2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KCNH2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Smooth Muscle Identity Cytoskeletal | ACTG2, ALDH1B1, C3orf70, CNN1, FBXL22, HSD17B6, JPH2, KCNMB1 +12 more | View in SCUBA |
| Hematopoietic progenitor cells | HPC Stemness Program Stemness | AMHR2, ARMC8, CASP3, CITED2, CNRIP1, CSF2RB, DLC1, FBXO7 +3 more | |
| Smooth muscle cells | FOXF2 Mesenchymal Patterning Development | ADAMTS6, APCDD1, BDKRB2, DCHS1, FAT4, FOXF2, MFAP5, P2RY14 +2 more | View in SCUBA |
About the gene
| Synonyms | erg1, HERG, Kv11.1, LQT2 |
|---|---|
| Chromosome | 7: 150944961-150978321 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels |
| Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
| Biological process | Ion transport, Potassium transport, Transport |
Function
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity. Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.