PDLIM7 — PDZ and LIM domain 7
PDLIM7 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDLIM7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Lipid Metabolism Metabolite transfer | ACSL4, APOL1, CDK2AP2, COPS8, GBE1, GOLM1, MAPRE1, NPC1 +5 more | View in SCUBA |
| Fibroblasts | Myofibroblast Contractile Cytoskeletal | ACTA2, CCDC107, CFL2, CSRP1, FLNA, ILK, LPP, MSRB3 +7 more | View in SCUBA |
| Macrophages | Inflammatory Monocyte Activation Inflammatory | ANPEP, AQP9, CD300E, CD82, CLEC5A, CXXC5, DDX60L, DHRS9 +25 more | View in SCUBA |
| Monocytes | Classical Monocyte Activation Inflammatory | CAPG, LGALS1, LYZ, MCEMP1, S100A8, S100A9, SERPINB1, TALDO1 +1 more | View in SCUBA |
| Neutrophils | Phagocytic Membrane Signaling Phagocytosis | APLP2, ATP6V1B2, CD44, CDC42EP3, CLIC1, EFHD2, FCER1G, FLOT1 +9 more | |
| Smooth muscle cells | Contractile SMC phenotype Contractility | ACTN1, CNN1, DES, KCNMB1, LBR, MYLK, SLMAP, SORBS1 +1 more | View in SCUBA |
About the gene
| Synonyms | ENIGMA |
|---|---|
| Chromosome | 5: 177483394-177497606 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Developmental protein |
| Biological process | Differentiation, Osteogenesis |
Function
May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.