Contractile SMC phenotype
Gene co-expression module in Smooth muscle cells
| Category | Contractility |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
Textbook contractile smooth muscle module: CNN1 (calponin), MYLK (myosin light chain kinase), DES (desmin), KCNMB1 (BK channel beta1, SMC-specific), SVIL (supervillin), SORBS1, PDLIM7, ACTN1 — dense body/actomyosin apparatus of differentiated SMCs. High expression and detection rate fit the dominant cell identity program. Neighbors M58/M47 provide the adhesion-plaque counterpart, supporting a coherent contractile-adhesion axis.
Genes
ACTN1, CNN1, DES, KCNMB1, LBR, MYLK, PDLIM7, SLMAP, SORBS1, SVIL
Most correlated modules
- SMC Contractile Signaling · correlation 0.87
- Microtubule biogenesis · correlation 0.82
- SMC focal adhesion · correlation 0.78
- Basement Membrane Matrix · correlation 0.78
- Mesenchymal Adhesion Program · correlation 0.77
- Integrin adhesion complex · correlation 0.76
- Basal metabolic housekeeping · correlation 0.74
- Growth Arrest Stress · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.