CDCA3 — Cell division cycle associated 3
CDCA3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDCA3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Mitotic Spindle Cell cycle | AURKB, CCNA2, CDCA8, CDK1, KIF2C, NDC80, NUF2, NUSAP1 +3 more | View in SCUBA |
| CD8⁺ T cells | G2/M Cell Cycle Cell cycle | CCNF, CDC25C, CDCA8, DEPDC1B, FAM83D, FBXO43, HJURP, PRC1 +1 more | View in SCUBA |
| Smooth muscle cells | Mitotic Spindle Cell cycle | AURKB, CCNA2, CDK1, KIF20A, MKI67, NUSAP1, PIMREG, SGO1 +4 more | View in SCUBA |
About the gene
| Synonyms | GRCC8, TOME-1 |
|---|---|
| Chromosome | 12: 6844793-6851292 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Mitosis, Ubl conjugation pathway |
Function
F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.