SGO1 — Shugoshin 1
SGO1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SGO1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Mitotic Spindle Cell cycle | CENPF, GTSE1, HMMR, KIF11, KIF22, KIFC1, NCAPG, SHCBP1 +3 more | View in SCUBA |
| CD8⁺ T cells | Mitosis & Cytokinesis Cell cycle | CDCA2, CEP55, CKAP2L, NUSAP1, RACGAP1, TACC3, TOP2A | View in SCUBA |
| Smooth muscle cells | Mitotic Spindle Cell cycle | AURKB, CCNA2, CDCA3, CDK1, KIF20A, MKI67, NUSAP1, PIMREG +4 more | View in SCUBA |
About the gene
| Synonyms | NY-BR-85, SGOL1 |
|---|---|
| Chromosome | 3: 20160593-20186206 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Chromosome partition, Mitosis |
Function
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.